Mercedes-Benz S-Class W221 Review (2006-2013)

Pros

  • Exceptionally luxurious and comfortable to travel in

  • Very well equipped

  • An awful lot of car for the money

Cons

  • High running costs

  • Potential for a very big bill if something goes wrong

  • V6 petrols can suffer from worn timing chain sprockets

4/5Overall score
Practicality
Driving
Tech and equipment
Running costs
2006-2013 Mercedes-Benz S-Class Generational Review summaryImage

The CarGurus verdict

Few cars feel as imperious or as plutocratic as an S-Class, and of them all, the W221 looks like the best value at the moment. Old enough to be affordable, yet still new enough to feel slick and luxurious, it’s also about as comfortable a car as you can get for the cash, and – if you pick the right model – it’s also surprisingly economical.

But don’t let that low purchase price fool you into thinking an S-Class will also be cheap to run. Maintenance costs will still be high, and unless you buy the later diesel model, you’ll also pay a fair bit for fuel too. What’s more, when things go wrong – and given there are a few big issues to keep in mind, that’s not impossible – you’ll have to stump up even more big bills.

As long as you keep all this in mind, though, the S-Class will offer you an ownership experience with which few other cars can compare. After all, luxury comes at a price – and given how much luxury the S-Class offers, it still feels like pretty reasonable value.

Search for a Mercedes-Benz S-Class on CarGurus

Are you the type of bargain hunter who wants a lot of used car for very little cash? If so, step this way, because we reckon we might have something here that’ll excite you.

It’s a Mercedes-Benz S-Class; the fifth-generation model, to be precise, also known as the W221 S-Class to aficionados. When new, it was often touted as the best car in the world. And quite frankly, it’s looking like a bit of a bargain at the moment, because while it’s still without doubt one of the most accomplished luxury cars out there, depreciation has driven values down so much that you can now buy an early example for the same sort of price as you’d pay for a used Volkswagen Golf.

  • A facelift for the S-Class was revealed in early 2009. You’d be hard pushed to tell the facelifted car from the earlier version, but you can spot the former thanks to its LED daytime running lights in the front bumper. Additional upgrades include an array of extra driver assistance features, including adaptive full beams and blind spot protection; a torque vectoring system that gently applies the brake to the inside rear wheel in bends to sharpen the car’s cornering; and the addition of pedestrian recognition to the night vision system.
  • Not content with just the one, Mercedes introduced two AMG versions of the S-Class. The S63 AMG comes with a 518bhp version of Mercedes’s famed 6.2-litre naturally-aspirated V8, allowing it to sprint to 62mph in 4.6 seconds. The S65 AMG is even faster, courtesy of its 6.0-litre twin-turbo V12 engine. It boasts a 4.4-second 0-62mph time and truly ballistic mid-range performance.
  • For most buyers, the common-or-garden S350 Bluetec is the one to have. Its big V6 diesel engine is quiet and smooth, offers more than enough shove for everyday motoring, and yet should also offer respectable fuel economy figures.

  • The S350 Bluetec only became available after the 2010 facelift, so if you’re buying on a budget it might be out of your reach. In that case, the S320 CDI turbodiesel is a pretty good substitute – it isn’t as economical, but it’s just as effortless in the way it delivers its power.
  • If a petrol engine is a must-have, then the S350 BlueEfficiency is the one we’d recommend. Thanks to a raft of clever fuel-saving measures, it’s nowhere near as inefficient as you might think a big petrol engine in a heavy luxury car would be; according to the official figures, in fact, it’s more economical than the pre-facelift diesel.
  • If it’s an AMG version you’re after, stick with the S63. As mighty as the S65 AMG looks on paper, its extra performance isn’t actually all that useable; what’s more, the S63 boasts a better soundtrack from its V8 engine as well as slightly more nimble handling thanks to its lighter engine.
Alex Robbins
Published 8 Sept 2021 by Alex Robbins
Alex used to be the used cars editor for What Car? and Autocar as well as the Daily Telegraph's consumer motoring editor. He covers all manner of new car news and road tests, but specialises in writing about used cars and modern classics. He's owned more than 40 cars, and can usually be found browsing the CarGurus classifieds, planning his next purchase.

Main rivals

Body styles

  • Four-door saloon